Publications

Publications scientifiques

Impact of resistant starch from high amylose wheat compared to inulin on human gut microbiota and host immune responses using an artificial colon associated to human leukocytes. Couturier I, Denis S, Rossary A, Despré D, Chalancon S, Durif C, Berbezy P, Caldefie-Chezet F, Blanquet-Diot S. Food Chem. 2026 522 Jun 2;522:149919. doi:
10.1016/j.foodchem.2026.149919.

A new in vitro model of the adult pig colon microbiome: application to the study of feed ingredients. Durif C, Denis S, Lemoine N, Deschamps C, Uriot O, Brun M, Guillou D, Blanquet-Diot S. Anim Microbiome. 2025 Oct 1;7(1):100.
10.1186/s42523-025-00465-1

Small intestine is not colon: a new in vitro model of the human ileum microbiome integrating the mucosal microenvironment and feeding status. Bron A, Beltramo C, Durif C, Arora T, Deschamps C, Couturier I, Domingo-Almenara X, Otero YF, Denis S, Van de Wiele T, Blanquet-Diot S. Gut Microbes. 2025 Dec 31;17(1):2579353.
10.1080/19490976.2025.2579353

Western diet-based NutriCol medium: A high-pectin, low-inulin culture medium promoted gut microbiota stability and diversity in PolyFermS and M-ARCOL continuous in vitro models. Esmail GA, Uriot O, Mottawea W, Denis S, Sultan S, Njoku EN, Chiba M, Tosh S, Blanquet-Diot S, Hammami R. Food Res Int. 2025 Apr;206:115993.
10.1016/j.foodres.2025.115993

Development of a new antibiotic-induced dysbiosis model of the canine colonic microbiota. Deschamps C, Apper E, Brun M, Durif C, Denis S, Humbert D, Blanquet-Diot S. Int J Antimicrob Agents. 2024 Feb 5:107102. doi:
10.1016/j.ijantimicag.2024.107102.
Epub ahead of print. PMID: 38325721.

Large intestinal nutritional and physicochemical parameters from different dog sizes reshape canine microbiota structure and functions in vitro. DESCHAMPS C., HUMBERT D., CHALANCON S., ACHARD C., APPER E., DENIS S., BLANQUET-DIOT S. (2024-03-12). Bioengineered, 15 (1),
10.1080/21655979.2024.2325713, https://hal.archives-ouvertes.fr/hal-04521783

Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes. Deschamps C, Denis S, Humbert D, Priymenko N, Chalancon S, De Bodt J, Van de Wiele T, Ipharraguerre I, Alvarez-Acero I, Achard C, Apper E, Blanquet-Diot S. Appl Microbiol Biotechnol. 2024 Jan 23;108(1):166. doi:
10.1007/s00253-023-12987-2.
PMID: 38261090; PMCID: PMC10806056.

Systèmes digestifs artificiels : applications en nutrition et santé canine. DESCHAMPS C., DENIS S., HUMBERT D., APPER E., BLANQUET-DIOT S. Bulletin de l’Académie Vétérinaire de France. 2023
Notice Persée : https://www.persee.fr/doc/bavf_0001-4192_2023_num_176_1_18285
DOI de la notice Persée : 10.3406/bavf.2023.18285
Autre DOI indiqué dans le fichier de l’article : 10.3406/bavf.2023.71041

EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects. VINCENTINI O., BLIER A., BOGNI A., BRUN M., CECCHETTI S., DE BATTISTIS F., DENIS S., ETIENNE‐MESMIN L., FERRARIS F., FUMAGALLI F., HOGEVEEN K., IACOPONI F., RAGGI A., SICILIANI L., STANCO D., VERLEYSEN E., FESSARD V., MAST J., BLANQUET‐DIOT S., BREMER‐HOFFMANN S., CUBADDA F. (2023-09-13). EFSA Supporting Publications, 20 (9), EN-8258,
10.2903/sp.efsa.2023.en-8258

Exposure to polyethylene microplastics alters immature gut microbiome in an infant in vitro gut model. Fournier E, Ratel J, Denis S, Leveque M, Ruiz P, Mazal C, Amiard F, Edely M, Bezirard V, Gaultier E, Lamas B, Houdeau E, Engel E, Lagarde F, Etienne-Mesmin L, Mercier-Bonin M, Blanquet-Diot S. J Hazard Mater. 2023 Feb 5;443(Pt B):130383. doi:
10.1016/j.jhazmat.2022.130383

In Vitro Modelling of Oral Microbial Invasion in the Human Colon. Etienne-Mesmin L, Meslier V, Uriot O, Fournier E, Deschamps C, Denis S, David A, Jegou S, Morabito C, Quinquis B, Thirion F, Plaza Oñate F, Le Chatelier E, Ehrlich SD, Blanquet-Diot S, Almeida M. Microbiol Spectr. 2023 Mar 27;11(2):e0434422. doi:
10.1128/spectrum.04344-22

Casein structures differently affect postprandial amino acid delivery through their intra-gastric clotting properties. Boulier A, Denis S, Henry G, Guérin S, Alric M, Meunier N, Blot A, Pereira B, Malpuech-Brugere C, Remond D, Boirie Y, Baniel A, Richard R, Dupont D, Boudry G. Food Chem. 2023 Jul 30;415:135779. doi:
10.1016/j.foodchem.2023.135779

Transfer of the Integrative and Conjugative Element ICESt3 of Streptococcus thermophilus in Physiological Conditions Mimicking the Human Digestive Ecosystem. Herviou P, Balvay A, Bellet D, Bobet S, Maudet C, Staub J, Alric M, Leblond-Bourget N, Delorme C, Rabot S, Denis S, Payot S. Microbiol Spectr. 2023 Jun 15;11(3):e0466722. doi:
10.1128/spectrum.04667-22

Differences in bread protein digestibility traced to wheat cultivar traits. LAVOIGNAT M., DENIS S., FAYE A., HALUPKA L., PERROCHON S., RHAZI L., GIRAUDEAU P., DEJEAN S., BRANLARD G., BANCEL E., RAVEL C. (2022-09). Journal of Cereal Science. 2022 107, 103533,
10.1016/j.jcs.2022.103533

A child is not an adult: development of a new in vitro model of the toddler colon. Fournier E, Denis S, Dominicis A, Van de Wiele T, Alric M, Mercier-Bonin M, Etienne-Mesmin L, Blanquet-Diot S. Appl Microbiol Biotechnol. 2022 Nov;106(21):7315-7336. doi:
10.1007/s00253-022-12199-0

From Chihuahua to Saint-Bernard: how did digestion and microbiota evolve with dog sizes. Deschamps C, Humbert D, Zentek J, Denis S, Priymenko N, Apper E, Blanquet-Diot S. Int J Biol Sci. 2022 Aug 1;18(13):5086-5102. doi:
10.7150/ijbs.72770

In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges. Deschamps C, Denis S, Humbert D, Zentek J, Priymenko N, Apper E, Blanquet-Diot S. ALTEX. 2022;39(2):235–257. doi:
10.14573/altex.2109011

Importance of oral phase in in vitro starch digestibility related to wholegrain versus refined pastas and mastication. BLANQUET-DIOT S., FRANCOIS O., DENIS S., HENNEQUIN M., PEYRON M.-A. 2021. doi:
10.1016/j.foodhyd.2020.106277

Impact of polyethylene microplastics on human gut microbiota as assessed in an in vitro gut model. FOURNIER E., ETIENNE-MESMIN L., DENIS S., VERDIER C., CHALANCON S., DURIF C., URIOT O., MERCIER-BONIN M., BLANQUET-DIOT S., COLLABORATION P. (2021-09). Toxicology Letters, 2021 350, S232-S233,
10.1016/S0378-4274(21)00781-5

Deciphering the influence of physicochemical and microbial parameters of the human digestive tract on orally-ingested microplastics using in vitro gut models. FOURNIER E., MERCIER-BONIN M., DENIS S., URIOT O., ROUSSEL C., LEVEQUE M., ALRIC M., VAN DE WIELE T., BLANQUET-DIOT S., ETIENNE-MESMIN L. (2021-09). Toxicology Letters, 2021 350, S109-S110,
10.1016/S0378-4274(21)00504-X

Saccharomyces Cerevisiae Var Boulardii CNCM I-1079 Reduces Expression of Genes Involved in Inflammatory Response in Porcine Cells Challenged by Enterotoxigenic E. Coli and Influences Bacterial Communities in an In Vitro Model of the Weaning Piglet Colon. Gresse R, Garrido JJ, Jiménez-Marín A, Denis S, Van de Wiele T, Forano E, Blanquet-Diot S, Chaucheyras-Durand F. Antibiotics (Basel). 2021 Sep 11;10(9):1101. doi:
10.3390/antibiotics10091101.
PMID: 34572682; PMCID: PMC8467900.

Nitric Oxide Impacts Human Gut Microbiota Diversity and Functionalities. Leclerc M, Bedu-Ferrari C, Etienne-Mesmin L, Mariadassou M, Lebreuilly L, Tran SL, Brazeau L, Mayeur C, Delmas J, Rué O, Denis S, Blanquet-Diot S, Ramarao N. mSystems. 2021 Oct 26;6(5):e0055821. doi:
10.1128/mSystems.00558-21.

Beneficial Effects of Natural Mineral Waters on Intestinal Inflammation and the Mucosa-Associated Microbiota. Barnich N, Rodrigues M, Sauvanet P, Chevarin C, Denis S, Le Goff O, Faure-Imbert D, Hanh T, Roques CF, Chassaing B, Alric M. Int J Mol Sci. 2021 Apr 21;22(9):4336. doi:
10.3390/ijms22094336.

Identification of Streptococcus thermophilus Genes Specifically Expressed under Simulated Human Digestive Conditions Using R-IVET Technology. Uriot O, Kebouchi M, Lorson E, Galia W, Denis S, Chalancon S, Hafeez Z, Roux E, Genay M, Blanquet-Diot S, Dary-Mourot A. Microorganisms. 2021 May 21;9(6):1113. doi:
10.3390/microorganisms9061113.

Use of the Dynamic TIM-1 Model for an In-Depth Understanding of the Survival and Virulence Gene Expression of Shiga Toxin-Producing Escherichia coli in the Human Stomach and Small Intestine. Uriot O, Chalancon S, Mazal C, Etienne-Mesmin L, Denis S, Blanquet-Diot S. Methods Mol Biol. 2021;2291:297-315. doi:
10.1007/978-1-0716-1339-9_14.

An Oral FMT Capsule as Efficient as an Enema for Microbiota Reconstruction Following Disruption by Antibiotics, as Assessed in an In Vitro Human Gut Model. Verdier C, Denis S, Gasc C, Boucinha L, Uriot O, Delmas D, Dore J, Le Camus C, Schwintner C, Blanquet-Diot S. Microorganisms. 2021 Feb 11;9(2):358. doi:
10.3390/microorganisms9020358.

Impact of oral galenic formulations of Lactobacillus salivarius on probiotic survival and interactions with microbiota in human in vitro gut models. Arnal ME, Denis S, Uriot O, Lambert C, Holowacz S, Paul F, Kuylle S, Pereira B, Alric M, Blanquet-Diot S. Benef Microbes. 2021 Aug 30;12(4):75-90. doi:
10.3920/BM2020.0187.

Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon (MPigut-IVM). Gresse R, Chaucheyras-Durand F, Denis S, Beaumont M, Van de Wiele T, Forano E, Blanquet-Diot S. J Anim Sci Biotechnol. 2021 Jun 2;12(1):75. doi:
10.1186/s40104-021-00584-0.

Pathogen Challenge and Dietary Shift Alter Microbiota Composition and Activity in a Mucin-Associated in vitro Model of the Piglet Colon (MPigut-IVM) Simulating Weaning Transition. Gresse R, Chaucheyras-Durand F, Garrido JJ, Denis S, Jiménez-Marín A, Beaumont M, Van de Wiele T, Forano E, Blanquet-Diot S. Front Microbiol. 2021 Jul 19;12:703421. doi:
10.3389/fmicb.2021.703421.

Multi-targeted properties of the probiotic saccharomyces cerevisiae CNCM I-3856 against enterotoxigenic escherichia coli (ETEC) H10407 pathogenesis across human gut models. Roussel C, De Paepe K, Galia W, de Bodt J, Chalancon S, Denis S, Leriche F, Vandekerkove P, Ballet N, Blanquet-Diot S, Van de Wiele T. Gut Microbes. 2021 Jan-Dec;13(1):1953246. doi:
10.1080/19490976.2021.1953246.

Benefits of the ipowder® extraction process applied to Melissa officinalis L.: improvement of antioxidant activity and in vitro gastro-intestinal release profile of rosmarinic acid. Bardot V, Escalon A, Ripoche I, Denis S, Alric M, Chalancon S, Chalard P, Cotte C, Berthomier L, Leremboure M, Dubourdeaux M. Food Funct. 2020 Jan 29;11(1):722-729. doi:
10.1039/c9fo01144g.
Erratum in: Food Funct. 2020 Jan 28.

Spatial and temporal modulation of enterotoxigenic E. coli H10407 pathogenesis and interplay with microbiota in human gut models. Roussel C, De Paepe K, Galia W, De Bodt J, Chalancon S, Leriche F, Ballet N, Denis S, Alric M, Van de Wiele T, Blanquet-Diot S. BMC Biol. 2020 Oct 14;18(1):141. doi:
10.1186/s12915-020-00860-x.

Can dynamic in vitro digestion systems mimic the physiological reality? Dupont D, Alric M, Blanquet-Diot S, Bornhorst G, Cueva C, Deglaire A, Denis S, Ferrua M, Havenaar R, Lelieveld J, Mackie AR, Marzorati M, Menard O, Minekus M, Miralles B, Recio I, Van den Abbeele P. Crit Rev Food Sci Nutr. 2019;59(10):1546-1562. doi:
10.1080/10408398.2017.1421900.

Comparison of conventional plating, PMA-qPCR, and flow cytometry for the determination of viable enterotoxigenic Escherichia coli along a gastrointestinal in vitro model. Roussel C, Galia W, Leriche F, Chalancon S, Denis S, Van de Wiele T, Blanquet-Diot S. 2018. Appl Microbiol Biotechnol. 102(22):9793-9802. doi:
10.1007/s00253-018-9380-z.

Anti-infectious properties of the probiotic Saccharomyces cerevisiae CNCM I-3856 on enterotoxigenic E. coli (ETEC) strain H10407. Roussel C, Sivignon A, de Vallée A, Garrait G, Denis S, Tsilia V, Ballet N, Vandekerckove P, Van de Wiele T, Barnich N, Blanquet-Diot S. 2018. Appl Microbiol Biotechnol. AMAB-D-17-02794R1. DOI:
10.1007/s00253-018-9053-y

Bacteriophages as modulator for the human gut microbiota: Release from dairy food systems and survival in a dynamic human gastrointestinal model. Samtlebe M, Denis S, Chalancon S, Atamer Z, Wagner N, Neve H, Franz C, Schmidt H, Blanquet-Diot S, Hinrichs J. 2018. Food Sci Technol. 91:235-41. DOI:
10.1016/j.lwt.2018.01.033

Environmental Pollutant Benzo[a]Pyrene Impacts the Volatile Metabolome and Transcriptome of the Human Gut Microbiota. Defois C, Ratel J, Denis S, Batut B, Beugnot R, Peyretaillade E, Engel E, Peyret P. 2017. Front Microbiol. 8:1562. DOI:
10.3389/fmicb.2017.01562

Streptococcus thermophilus: From yogurt starter to a new promising probiotic candidate? Uriot O, Denis S, Junjua M, Roussel Y, Dary-Mourot A, Blanquet-Diot S. 2017. J Functional Foods. 37:74-89. DOI: 10.1016/j.jff.2017.07.038

Development and validation of a new dynamic in vitro model of the piglet colon (PigutIVM): application to the study of probiotics. Fleury MA, Le Goff, Denis S, Chaucheyras-Durand F, Jouy E, Kempf I, Alric M, Blanquet-Diot S. 2017. Appl Microbiol Biotechnol. 101(6):2533-47. DOI:
10.1007/s00253-017-8122-y

Digestion of cooked meat proteins is slightly affected by age as assessed using the dynamic gastrointestinal TIM model and mass spectrometry. Denis S, Sayd T, Georges A, Chambon C, Chalancon S, Santé-Lhoutellier V, Blanquet-Diot S. 2016. Food Funct. 7(6):2682-91. DOI:
10.1039/c6fo00120c

Development and validation of a new dynamic computer-controlled model of the human stomach and small intestine. Guerra A, Denis S, Le Goff O, Sicardi V, François O, Yao AF, Garrait G, Manzi AP, Beyssac E, Alric M, Blanquet-Diot S. 2016. Biotechnol Bioeng. 113(6):1325-35. DOI: 10.1002/bit.25890

Survie et activité de bioconversion de levures génétiquement modifiées in vivo chez le rat. Garrait G, Jarrige JF, Blanquet S, Denis S, Beyssac E, Cardot JM, Alric M. 2004. Cahiers de Nutrition et de Diététique. 39(1):55-84. Notice éditeur :
EM-Consulte

An application of specific sensors for the monitoring of NaCl in soft cheeses. Lvova L, Mielle P, Salles C, Denis S, Vergoignan C, Barra A, Di Natale C, Paolesse R, Temple-Boyer P, Féron G. 2011. Olfaction and Electronic Nose: Proceedings of the 14th International Symposium on Olfaction and Electronic Nose. AIP Conference Proceedings, Volume 1362, Issue 1, p.84-85. DOI:
10.1063/1.3626315

Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. Agus A, Denizot J, Thévenot J, Martinez-Medina M, Massier S, Sauvanet P, Bernalier-Donadille A, Denis S, Hofman P, Bonnet R, Billard E, Barnich N. 2016. Sci Rep. 6:19032. DOI:
10.1038/srep19032

Use of the dynamic gastro-intestinal model TIM to explore the survival of the yogurt bacterium Streptococcus thermophilus and the metabolic activities induced in the simulated human gut. Uriot O, Galia W, Ablavi Awussi A, Perrin C, Denis S, Chalancon S, Lorson E, Poirson C, Junjua M, Le Roux Y, Alric M, Dary A, Blanquet-Diot S, Roussel Y. 2016. Food Microb. 53:18-29. DOI: 10.1016/j.fm.2015.05.007

In vitro digestion of biscuits enriched in proteins and/or fibres using a multi-compartmental and dynamic system (2): protein and starch hydrolyses. Villemejane C, Denis S, Marsset-Baglieri A, Aymard P, Alric M, Michon C. 2016. Food Chem. 190:164-172. DOI: 10.1016/j.foodchem.2015.05.050

In vitro digestion of short-dough biscuits enriched in proteins and/or fibres, using a multi-compartmental and dynamic system (1): Viscosity measurement and prediction. Villemejane C, Wahl R, Aymard P, Denis S, Michon C. 2015. Food Chem. 182:55-63. DOI: 10.1016/j.foodchem.2015.02.125

Enterohemorrhagic Escherichia coli infection has donor-dependent effect on human gut microbiota and may be antagonized by probiotic yeast during interaction with Peyer’s patches. Thévenot J, Cordonnier C, Rougeron A, Le Goff O, Nguyen HTT, Denis S, Alric M, Livrelli V, Blanquet-Diot S. 2015. Appl Microbiol Biotechnol. 99(21):9097-110. DOI:
10.1007/s00253-015-6704-0

Insights into bread melanoidins: fate in the upper digestive tract and impact on the gut microbiota using in vitro systems. Helou C, Denis S, Spatz M, Marier D, Rame V, Alric M, Tessier FJ, Gadonna-Widehem P. 2015. Food Funct. 6(12):3737-45. DOI:
10.1039/c5fo00836k

Dynamic In Vitro Models of the Human Gastrointestinal Tract as Relevant Tools to Assess the Survival of Probiotic Strains and Their Interactions with Gut Microbiota. Cordonnier C, Thévenot J, Etienne-Mesmin L, Denis S, Alric M, Livrelli V, Blanquet-Diot S. 2015. Microorganisms. 3(4):725-45. DOI:
10.3390/microorganisms3040725

Survival of pathogenic and lactobacilli species of fermented olives during simulated human digestion. Arroyo-López FN, Blanquet-Diot S, Denis S, Thévenot J, Chalancon S, Alric M, Rodríguez-Gómez F, Romero-Gil V, Jiménez-Díaz R. 2014. Front Microbiol. 5:540. DOI: 10.3389/fmicb.2014.00540

Survival of Escherichia coli O26:H11 exceeds that of Escherichia coli O157:H7 as assessed by simulated human digestion of contaminated raw milk cheeses. Miszczycha SD, Thévenot J, Denis S, Callon C, Livrelli V, Alric M, Montel MC, Blanquet-Diot S, Thevenot-Sergentet D. 2014. Int J Food Microbiol. 172:40-8. DOI:
10.1016/j.ijfoodmicro.2013.11.029

Enterohemorrhagic Escherichia coli O157:H7 survival in an in vitro model of the human large intestine and interactions with probiotic yeasts and resident microbiota. Thévenot J, Etienne-Mesmin L, Denis S, Chalancon S, Alric M, Livrelli V, Blanquet-Diot S. 2013. Appl Environ Microbiol. 79(3):1058-64. DOI:
10.1128/AEM.03303-12

Relevance and challenges in modeling human gastric and small intestinal digestion. Guerra A, Etienne-Mesmin L, Livrelli V, Denis S, Blanquet-Diot S, Alric M. 2012. Trends Biotechnol. 30(11):591-600. DOI:
10.1016/j.tibtech.2012.08.001

Salt release monitoring with specific sensors in « in vitro » oral and digestive environments from soft cheeses. Lvova L, Denis S, Barra A, Mielle P, Salles C, Vergoignan C, Di Natale C, Paolesse R, Temple-Boyer P, Feron G. 2012. Talanta. 97:171-80. DOI:
10.1016/j.talanta.2012.04.013

Use of artificial digestive systems to investigate the biopharmaceutical factors influencing the survival of probiotic yeast during gastrointestinal transit in humans. Blanquet-Diot S, Denis S, Chalancon S, Chaira F, Cardot JM, Alric M. 2012. Pharm Res. 29(6):1444-53. DOI:
10.1007/s11095-011-0620-5

In vitro maintenance of a human proximal colon microbiota using the continuous fermentation system P-ECSIM. Feria-Gervasio D, Denis S, Alric M, Brugère JF. 2011. Appl Microbiol Biotechnol. 91(5):1425-33. DOI:
10.1007/s00253-011-3462-5

Effect of a new probiotic Saccharomyces cerevisiae strain on the survival of Escherichia coli O157:H7 in a dynamic gastrointestinal model. Etienne-Mesmin L, Livrelli V, Privat M, Denis S, Cardot JM, Alric M, Blanquet-Diot S. 2011. Appl Environ Microbiol. 77:1127-31. DOI:
10.1128/AEM.02130-10

Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2). Torres-Escribano S, Denis S, Blanquet-Diot S, Calatayud M, Barrios L, Vélez D, Alric M, Montoro R. 2011. Sci Total Environ. 409:604-11. DOI:
10.1016/j.scitotenv.2010.10.021

In vitro study of the release properties of soy-zein protein microspheres with a dynamic artificial digestive system. Chen L, Hébrard G, Beyssac E, Denis S, Subirade M. 2010. J Agric Food Chem. 58(17):9861-7. DOI:
10.1021/jf101918w

Combining the dynamic TNO-gastrointestinal tract system with a Caco-2 cell culture model: application to the assessment of lycopene and alpha-tocopherol bioavailability from a whole food. Déat E, Blanquet-Diot S, Jarrige JF, Denis S, Beyssac E, Alric M. 2009. J Agric Food Chem. 57:11314-20. DOI:
10.1021/jf902392a

Evaluation of a dynamic in vitro model to simulate the porcine ileal digestion of diets differing in carbohydrate composition. Meunier JP, Manzanilla EG, Anguita M, Denis S, Pérez JF, Gasa J, Cardot JM, Garcia F, Moll X, Alric M. 2008. J Anim Sci. 86:1156-63. DOI:
10.2527/jas.2007-0145

Investigation of the biopharmaceutical behavior of theophylline hydrophilic matrix tablets using USP methods and an artificial digestive system. Souliman S, Beyssac E, Cardot JM, Denis S, Alric M. 2007. Drug Dev Ind Pharm. 33:475-83. DOI:
10.1080/03639040601128654

Effects of cryoprotectants on the viability and activity of freeze dried recombinant yeasts as novel oral drug delivery systems assessed by an artificial digestive system. Blanquet S, Garrait G, Beyssac E, Perrier C, Denis S, Hebrard G, Alric M. 2005. Eur J Pharm Biopharm. 61(1-2):32-39. DOI:
10.1016/j.ejpb.2005.03.009

A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Blanquet S, Zeijdner E, Beyssac E, Meunier JP, Denis S, Havenaar R, Alric M. 2004. Pharm Res. 21(4):585-91. DOI:
10.1023/B:PHAM.0000022404.70478.4B

Living recombinant Saccharomyces cerevisiae secreting proteins or peptides as a new drug delivery system in the gut. Blanquet S, Antonelli R, Laforet L, Denis S, Marol-Bonnin S, Alric M. 2004. J Biotechnol. 110(1):37-49. DOI:
10.1016/j.jbiotec.2004.01.012

Degradation and product analysis of caffeine and related dimethylxanthines by filamentous fungi. Hakil M, Denis S, Viniegra-González G, Augur C. 1998. Enzyme Microb Tech. 22:355-359. DOI:
10.1016/S0141-0229(97)00205-6

A new HPLC analytical method to study fungal caffeine metabolism. Denis S, Augur C, Roussos S, Marin B. 1998. Biotechnol Tech. 12:359-362. DOI:
10.1023/A:1008866113065